Health & Wellness

6 Things a Gut Health Scientist Wants You to Understand Before You Buy a Single Supplement

Maggie Ekberg
March 11, 2026
6 Things a Gut Health Scientist Wants You to Understand Before You Buy a Single Supplement
Image: Cora Pursley/Dupe

At some point in the last few years, “gut health” turned into an entire personality. Suddenly everyone’s taking five probiotics, drinking a $14 kombucha, and adding mysterious powders to their smoothies like they’re conducting a science experiment in their kitchen.

Meanwhile you’re just over here wondering why you’re suddenly bloated after foods you used to eat without thinking, fiending for sugar like your life depends on it, or gaining weight even though your routine hasn’t changed.

According to microbiome scientist Dr. Colleen Cutcliffe on The Gabby Reece Show, your gut actually does influence a lot more than people realize—from cravings to metabolism to immune health. But before you panic-buy another probiotic, she says there are a few things worth understanding first.

☐ Know that your gut is running way more than just your digestion

“There’s 11 organ systems in your body that are important for your health,” Dr. Cutcliffe says. “And what we now know is that the microbiome is at the center of them and is connected to all 11.” Which means your gut isn’t just handling digestion. It’s influencing your weight, cravings, sleep, skin, mood, hormones, and a lot of the things people tend to blame on “getting older” or being stressed.

The good news is that unlike your DNA, the microbiome can actually change. What you eat, how you sleep, your stress levels, even the environment around you all shape it over time.

☐ Hit three grocery store sections before you touch a supplement

Before you start stacking probiotics like Pokémon cards, Dr. Cutcliffe says to start in three places at the grocery store: the produce section, the spice aisle, and the beans and legumes. “If you can really up your game there, that might be good enough for you,” she says.

Those foods feed the microbes that keep your gut functioning. More vegetables, more spices, more fiber from beans and lentils. Just maybe don’t go from zero fiber to a full lentil lifestyle overnight.

☐ Flip over that “gut healthy” product and read the back

The wellness aisle is full of products promising to help your gut, but Dr. Cutcliffe says a lot of them don’t hold up when you actually read the label. “People are like, ‘This is good for your gut because it has probiotics in it,’” she says. “And then they’ve dumped 30 grams of sugar along with it.”

That probiotic gummy, gut soda, or “clean” yogurt might sound impressive on the front of the package, but if it’s loaded with sugar, it’s working against you no matter how good the marketing sounds.

☐ Stop blaming yourself for your sweet tooth

If you’ve ever had one of those afternoons where you’re suddenly on a mission for something sweet—like your brain will not shut up about cookies, chocolate, or whatever’s in the office snack drawer—you’re not imagining it. “Without the right amount of GLP-1 at the right time, your food cravings are all out of whack,” Dr. Cutcliffe explains.

Certain microbes in your gut literally send signals to your brain about what to eat. If the wrong ones are running the show, they start requesting the wrong foods. That 3 p.m. sugar craving that feels impossible to override? It might not be a willpower problem, but a staffing issue in your gut.

☐ Give anything you try a full 90 days

Trying a probiotic or gut supplement and expecting to feel different in a week is basically setting yourself up for disappointment. Your gut doesn’t move that fast.

Dr. Cutcliffe says to treat it like an experiment instead of expecting overnight results. “Keep everything else as consistent as possible,” she says. “Add the thing to your routine and monitor if you’re feeling or seeing any changes.”

It takes about eight weeks for your microbiome to fully shift after a major diet change—like going from carnivore to vegetarian—so real changes take time to show up. “If you don’t feel any change within 90 days, move on to the next idea,” she suggests. Not two weeks. Not a month. Ninety actual days.

☐ Aim for a resilient gut, not a perfect one

A lot of gut advice online makes it sound like one off-plan meal will ruin everything. Dr. Cutcliffe says that’s not how the microbiome works. “A healthy gut is actually a resilient gut,” she explains. “Things can come at you. You can eat poorly one day. You can be under stress. You can have bad sleep…but you’re resilient because you’re foundationally really strong.”

In real life, that just means your gut can handle the occasional travel day, late night, takeout dinner, or stressful week without everything completely falling apart. What you’re really trying to build is a foundation that can recover quickly when life inevitably throws those things your way.

Want the full breakdown straight from Dr. Cutcliffe? You can listen to the complete episode on The Gabby Reece Show, wherever you get your podcasts.


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